There are several readily identifiable causes of reduced theophylline clearance. Smokers Tobacco and marijuana smoking appears to increase the clearance of theophylline by induction of metabolic pathways. Theophylline clearance has been shown to increase by approximately 50% in young adult tobacco smokers and by approximately 80% in elderly tobacco smokers compared to non-smoking subjects. Passive smoke exposure has also been shown to increase theophylline clearance by up to 50%. Abstinence from tobacco smoking for one week causes a reduction of approximately 40% in theophylline clearance. Careful attention to dose reduction and frequent monitoring of serum theophylline concentrations are required in patients who stop smoking see . Use of nicotine gum has been shown to have no effect on theophylline clearance. ferh.info bactrim
What is theophylline Theo-24? Quibron-T may interfere with certain lab tests. Be sure your doctor and lab personnel know you are taking Quibron-T. Carcinogenesis studies and animal reproduction studies have not been performed with Infasurf. A single mutagenicity study Ames assay was negative. FDA pregnancy category C. This medication may be harmful to an unborn baby. artane
Administer multiple dose oral activated charcoal and measures to control emesis. This product has not been found by the US FDA to be safe and effective and the product labeling has not been approved. While the mechanisms of action of theophylline are not known with certainty, studies in animals suggest that bronchodilatation is mediated by the inhibition of two isozymes of phosphodiesterase PDE III and, to a lesser extent, PDE IV while non-bronchodilator prophylactic actions are probably mediated through one or more different molecular mechanisms, that do not involve inhibition of PDE III or antagonism of adenosine receptors. clarinex online ohne rezept
Take this medication regularly to get the most benefit from it. To help you remember, take it at the same times each day. Keep taking this medication even if you feel well. Do not increase your dose, take this drug more often, or stop taking it without first consulting your doctor. Use Quibron as directed by your doctor. Check the label on the medicine for exact dosing instructions. During the initiation of theophylline therapy, caffeine-like adverse effects may transiently alter patient behavior, especially in school age children, but this response rarely persists. generic periactin roche
HPLC techniques. Caffeine and xanthine metabolites in neonates or patients with renal dysfunction may cause the reading from some dry reagent office methods to be higher than the actual serum theophylline concentration. What other drugs will affect Quibron guaifenesin and theophylline? Each bead is an individual extended-release delivery system. If symptoms are controlled and current dosage is tolerated, maintain dose and recheck serum concentration at 6-12 month intervals. Many drugs can interact with guaifenesin and theophylline. Below is just a partial list. Safety and efficacy have not been established in patients younger than 12 years. During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor. Changes in your body during the last 3 months of pregnancy may affect the amount of this drug in your blood. Your doctor should carefully monitor the amount of drug in your blood, as well as any side effects, so that your dose may be changed if needed. Where can I get more information?
Drinking alcohol may increase the risk of side effects of Quibron-T. Talk to your doctor before drinking alcohol while you are taking Quibron-T. SD where actual range not reported. What should I avoid while taking theophylline Theo-24? Get medical help right away if you have any very serious side effects, including: seizures. General Monitoring Procedures Electrocardiographic monitoring should be initiated on presentation and continued until the serum theophylline level has returned to a non-toxic level. Serum electrolytes and glucose should be measured on presentation and at appropriate intervals indicated by clinical circumstances. Fluid and electrolyte abnormalities should be promptly corrected. Most serum theophylline assays in clinical use are immunoassays which are specific for theophylline. Other xanthines such as caffeine, dyphylline, and pentoxifylline are not detected by these assays. Smyrna, GA 30080. by Pfizer Pharmaceuticals LLC Caguas, PR 00725. Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. Consult your doctor before -feeding. atarax
Safety and efficacy of this drug has not been established; its limited use in pediatric patients has been inadequate to fully define the proper dosage and limitations of use. Treatment of seizures Because of the high morbidity and mortality associated with theophylline-induced seizures, treatment should be rapid and aggressive. What should I avoid while taking Quibron guaifenesin and theophylline? Decrease dose by 25% even if no adverse effects are present. Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Wolters Kluwer Health and Drugs. order cheapest hyzaar store usa hyzaar
Animal Metabolism: Infasurf is administered directly to the lung lumen surface, its site of action. No human studies of absorption, biotransformation, or excretion of Infasurf have been performed. The administration of Infasurf with radiolabeled phospholipids into the lungs of adult rabbits results in the persistence of 50% of radioactivity in the lung alveolar lining and25% of radioactivity in the lung tissue 24 hours later. Less than 5% of the radioactivity is found in other organs. In premature lambs with lethal surfactant deficiency, less than 30% of instilled Infasurf is present in the lung lining after 24 hours. Theophylline can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby. Tablets are contraindicated in patients with a history of hypersensitivity to theophylline or other components in the product. Dosage reduction may alleviate the caffeine-like adverse effects in these patients, however, persistent adverse effects should result in a reevaluation of the need for continued theophylline therapy and the potential therapeutic benefit of alternative treatment. To guide a dose increase, the blood sample should be obtained at the time of the expected peak serum theophylline concentration; 5-6 hours after a dose at steady-state, drawn more than 6 hours after the dose. For most patients, steady-state will be reached after 3 days of dosing when no doses have been missed, no extra doses have been added, and none of the doses have been taken at unequal intervals. Halothane sensitizes the myocardium to catecholamines, theophylline increases release of endogenous catecholamines. This medicine may add to the central nervous system CNS stimulant effects of caffeine-containing foods or beverages such as chocolate, cocoa, tea, coffee, and cola drinks. Avoid eating or drinking large amounts of these foods or beverages while using this medicine. If you have questions about this, check with your doctor. Talk to your doctor before making changes in your diet. Uniphyl 400 or 600 mg tablets can be taken once a day in the morning or evening. No food-fasting conditions were imposed in the study. Dobin R. Lettre à l'éditeur: Synthroid a record de sécurité et d'efficacité. Wall Street Journal, le 20 Juin 2001. buy stendra in toronto
Notify your doctor if you develop a new illness, especially if it is accompanied by fever; if a chronic illness becomes worse; if you start or stop smoking cigarettes or marijuana; or if another doctor prescribes a new medication or tells you to stop using a medication that you have already been taking. Caffeine has demonstrated the ability to reduce pulmonary resistance and increase lung compliance with a concomitant reduction in the requirement for inspired oxygen in preterm infants. These observations were not associated with increased mortality. Some MEDICINES MAY INTERACT with Quibron. Decreases theophylline clearance by inhibiting cytochrome P450 1A2. Doing so can release all of the drug at once, increasing the risk of side effects. Also, do not split the tablets unless they have a score line and your doctor or pharmacist tells you to do so. Swallow the whole or split tablet without crushing or chewing. To guide a dose increase, the blood sample should be obtained at the time of the expected peak serum theophylline concentration; 1-2 hours after a dose at steady-state. For most patients, steady-state will be reached after 3 days of dosing when no doses have been missed, no extra doses have been added, and none of the doses have been taken at unequal intervals. What happens if I miss a dose Theo-24? There are no adequate and well-controlled studies in pregnant women.
In selected patients at high risk for theophylline-induced seizures, consideration should be given to the administration of prophylactic anticonvulsant therapy. Fluid and electrolyte abnormalities should be promptly corrected. Studies in women suggest that this medication poses minimal risk to the infant when used during breastfeeding. Fever Fever, regardless of its underlying cause, can decrease the clearance of theophylline. The magnitude and duration of the fever appear to be directly correlated to the degree of decrease of theophylline clearance. Acute Clinical Effects: As with other surfactants, marked improvements in oxygenation and lung compliance may occur shortly after the administration of Infasurf. All controlled clinical trials with Infasurf demonstrated significant improvements in fraction of inspired oxygen FiO2 and mean airway pressure MAP during the first 24 to 48 hours following initiation of Infasurf therapy. Refer to for information regarding table. Patients should be instructed to inform all clinicians involved in their care that they are taking theophylline, especially when a medication is being added or deleted from their treatment. Patients should be instructed to not alter the dose, timing of the dose, or frequency of administration without first consulting their clinician. If a dose is missed, the patient should be instructed to take the next dose at the usually scheduled time and to not attempt to make up for the missed dose. Increases theophylline clearance by induction of microsomal enzyme activity. Theophylline is safe and effective for the approved indications in pediatric patients. Serum Concentrations at Steady State After multiple doses of immediate-release theophylline, steady state is reached in 30-65 hours average 40 hours in adults. At steady state, on a dosage regimen with 6-hour intervals, the expected mean trough concentration is approximately 60% of the mean peak concentration, assuming a mean theophylline half-life of 8 hours. The difference between peak and trough concentrations is larger in patients with more rapid theophylline clearance. In patients with high theophylline clearance and half-lives of about 4-5 hours, such as children age 1 to 9 years, the trough serum theophylline concentration may be only 30% of peak with a 6-hour dosing interval. purchase estradiol manufacturer
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This medication can cause side effects that may impair your thinking or reactions. Lab tests, including blood theophylline levels, may be performed while you use Quibron-T. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments. To reduce your risk of side effects, your doctor may direct you to start this medication at a low dose and gradually increase your dose. Follow your doctor's instructions carefully. Erythromycin metabolite decreases theophylline clearance by inhibiting cytochrome P450 3A3. This is not a complete list of side effects and others may occur. prograf
Distribution Once theophylline enters the systemic circulation, about 40% is bound to plasma protein, primarily albumin. Unbound theophylline distributes throughout body water, but distributes poorly into body fat. Decreases renal clearance of theophylline. Table V contains theophylline dosing titration schema recommended for patients in various age groups and clinical circumstances. Table VI contains recommendations for theophylline dosage adjustment based upon serum theophylline concentrations. Application of these general dosing recommendations to individual patients must take into account the unique clinical characteristics of each patient. In general, these recommendations should serve as the upper limit for dosage adjustments in order to decrease the risk of potentially serious adverse events associated with unexpected large increases in serum theophylline concentration. Table V. Dosing initiation and titration as anhydrous theophylline. midamor
Anticipate need for anticonvulsants. Always consult a healthcare professional for medical advice. If you have any questions about Quibron, please talk with your doctor, pharmacist, or other health care provider. The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables. price for ranexa prescription
Do not start or stop smoking without first talking to your doctor. Smoking changes the way your body uses theophylline, and you may need to use a different dose. Some medical conditions may interact with Quibron-T. St. John's wort or vitamin supplements. Carter BL, Driscoll CE, Smith GD "Theophylline clearance during pregnancy.